Alpha‐synuclein mRNA expression in sporadic Parkinson's disease
Identifieur interne : 001538 ( Main/Exploration ); précédent : 001537; suivant : 001539Alpha‐synuclein mRNA expression in sporadic Parkinson's disease
Auteurs : Eng-King Tan [Singapour] ; Van R. Chandran [Singapour] ; Stephanie Fook-Chong [Singapour] ; Hui Shen [Singapour] ; Kenneth Yew [Singapour] ; Mei-Lin Teoh [Singapour] ; Yih Yuen [Singapour] ; Yi Zhao [Singapour]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-05.
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- KwdEn :
Abstract
The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society
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DOI: 10.1002/mds.20391
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-05">2005-05</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="620">620</biblScope><biblScope unit="page" to="623">623</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">22991D4EF9D3A25548988076711F3470F8837357</idno><idno type="DOI">10.1002/mds.20391</idno><idno type="ArticleID">MDS20391</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>alpha‐synuclein</term><term>gene dosage</term><term>mRNA</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The expression of α‐synuclein gene can be influenced by the genomic load and/or epigenetic factors. By using quantitative real‐time polymerase chain reaction techniques, we demonstrated that the α‐synuclein gene mRNA expression in sporadic PD did not differ from healthy controls (median [range] 0.110 ]0.012–0.628] vs. 0.120 [0.028–0.447]; P = 0.15). There was no difference in the α‐synuclein gene dosage between PD patients with high and low mRNA expression. Multivariate analysis did not reveal age, gender, or cigarette smoking as confounding variables. Our study suggests that there was no significant alteration of α‐synuclein mRNA expression in our sporadic PD patients compared to controls. However, the role of α‐synuclein mRNA expression in select groups of sporadic PD patients and its interaction with environmental agents need to be further determined. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><country name="Singapour"><noRegion><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name></noRegion><name sortKey="Chandran, Van R" sort="Chandran, Van R" uniqKey="Chandran V" first="Van R." last="Chandran">Van R. Chandran</name><name sortKey="Fook Hong, Stephanie" sort="Fook Hong, Stephanie" uniqKey="Fook Hong S" first="Stephanie" last="Fook-Chong">Stephanie Fook-Chong</name><name sortKey="Shen, Hui" sort="Shen, Hui" uniqKey="Shen H" first="Hui" last="Shen">Hui Shen</name><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><name sortKey="Tan, Eng Ing" sort="Tan, Eng Ing" uniqKey="Tan E" first="Eng-King" last="Tan">Eng-King Tan</name><name sortKey="Teoh, Mei In" sort="Teoh, Mei In" uniqKey="Teoh M" first="Mei-Lin" last="Teoh">Mei-Lin Teoh</name><name sortKey="Yew, Kenneth" sort="Yew, Kenneth" uniqKey="Yew K" first="Kenneth" last="Yew">Kenneth Yew</name><name sortKey="Yuen, Yih" sort="Yuen, Yih" uniqKey="Yuen Y" first="Yih" last="Yuen">Yih Yuen</name><name sortKey="Zhao, Yi" sort="Zhao, Yi" uniqKey="Zhao Y" first="Yi" last="Zhao">Yi Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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